Department of Medical Biology

Assoc. Prof. Zülfinaz Betül ÇELİK

Basic Medical Sciences, Department of Medical Biology, Samsun University Faculty of Medicine

Education: Gazi University, Faculty of Science, Biology (Undergraduate, 2010)

Gazi University, Graduate School of Natural and Applied Sciences, Department of Molecular Biology (M.Sc., 2013)

Ondokuz Mayıs University, Institute of Health Sciences, Department of Medical Biology (PhD, 2019)

Research Areas: Investigation of Genetic and Epigenetic mechanisms associated with autoimmune and inflammatory diseases. Investigation of epigenetic changes associated with cancer and neurodegenerative diseases. Investigation of the mechanisms of action of pharmacological agents that can be used in inflammatory and neurodegenerative diseases in in vitro and in vivo models.

Selected Works: She has 16 articles published in SCI and 3 articles published in non-SCI indexes. She also has 25 papers published in international and national congresses and conferences.

Alterations in the matrix metalloproteinase-3 promoter methylation after common chemotherapeutics: In vitro study of paclitaxel, cisplatin and methotrexate in the MCF-7 and SH-SY5Y cell lines. Molecular Biology Reports. 2020;47:8987-8995.

Upregulation of microRNA-93-5p/microRNA-4668-5p, and promoter methylation of matrix metalloproteinase-3 and interleukin-16 genes in Turkish patients with rheumatoid arthritis. The Egyptian Rheumatologist. 2021;43(1):35-39.

Cannabinoid receptor-1 has an effect on CD200 under rotenone and alpha-synuclein induced stress. Neuroscience Letters. 2021;755:135908.

SAHA attenuates rotenone-induced toxicity in primary microglia and HT-22 cells. Toxicology and Industrial Health. 2021;37(1):23-33.

Cannabinoid receptors modulate LPS-induced increase of class-II transactivator expression levels in a microglial cell line. Journal of Receptors and Signal Transduction. 2021;41(3):209-216.

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signalling pathway in collagen induced arthritis model. BioFactors. 2019;45(1):69-74.

Projects: She is a researcher in the project titled “Could the alpha-synuclein-LRRK2-LAG3 triad be a possible drug target in the treatment of Parkinson’s disease?” numbered 6873 supported by TUSEB. In addition, she worked as a researcher in three scientific research projects supported by the university between 2017-2020.

Assist. Prof. Dr. Zülfinaz Betül Çelik is a member of the Association of Medical Biology and Genetics.

Office: Samsun University Faculty of Medicine, Canik Campus Gürgenyatak Mahallesi Merkez Sokak No:40-2/1 CANİK/SAMSUN

e-mail: [email protected]

Tel: 0362 313 00 55

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Assist. Prof. Özlem CESUR GÜNAY

Basic Medical Sciences, Department of Medical Biology, Samsun University Faculty of Medicine

Education: Ondokuz Mayis University (Undergraduate)

University of Leeds, England (MSc, PhD)

Research Areas: Cell Biology, Molecular Virology, Cervical cancer, Cancer causing viruses (Human Papilloma Virus), Polymerase Chain Reaction (PCR), Western Blotting, Co-immunoprecipitation (Co-IP), Molecular cloning, Recombinant protein expression, Protein purification, Immunofluorescence imaging, Quantitative Real-Time PCR, Apoptosis assays, RNA biology, in vitro RNA synthesis, RNA aptamers, Flow Cytometry, Polymorphism analyses, PCR-Restriction Fragment Length Polymorphism (PCR-RFLP).

Selected Studies: The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers. Viruses, 7(7), 3443-3461 (2015). An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein. PLoS One, 8(5), e64781 (2013). IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others? J Invest Dermatol, 134(3), 852-855, (2014). An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein. Cancers (Basel), 6(3), 1553-1569 (2014). Effect of Mi Gene and Nematode Resistance on Tomato Genotypes Using Molecular and Screening Assay, Cytology and Genetics, 54, 2, 154-164 (2020). 16S rRNA and Simple Bioinformatic Analyses in Microbiota. Journal of Bıotechnology and Strategıc Health Research, 2(1), 23-34 (2018).

Office: Samsun University Faculty of Medicine, Canik Campus Gürgenyatak Mahallesi Merkez Sokak No:40-2/1 CANİK/SAMSUN

e-mail: [email protected]

Tel:+90 (362) 313 00 55

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ANNOUNCEMENTS

Associate Professorship Congratulations

Muhammed Mustafa KURT, faculty member of the Department of Surgical Sciences, Department of Ophthalmology, has become an associate professor. Our teacher, Assoc. Prof. We congratulate Muhammed Mustafa KURT and wish him continued success.

Associate Professorship Congratulations

Lokman KEHRIBAR, a faculty member of the Department of Surgical Sciences, Department of Orthopedics and Traumatology, has become an associate professor. Our teacher, Assoc. Prof. We congratulate Lokman KEHRIBAR and wish him continued success.

Associate Professorship Congratulations

Mesut OZTURK, a faculty member of the Department of Internal Medicine, Department of Radiology, has become an associate professor. Our teacher, Assoc. Prof. We congratulate Mesut OZTURK and wish him continued success.

Associate Professorship Congratulations

Enes GURUN, a faculty member of the Department of Internal Medicine, Department of Radiology, has become an associate professor. Our teacher, Assoc. Prof. We congratulate Enes GURUN and wish him continued success.